Guhanga udushya IVD Kugaragaza Impinduramatwara Gusuzuma Arbovirus

Virusi ya Zika, umwe mu bagize umuryango wa Flaviviridae, yanduza cyane cyane abantu binyuze mu kurumwa n'umubu wa Aedes wanduye, nka Aedes aegypti na Aedes albopictus. Iyi virusi yamenyekanye bwa mbere mu 1947 mu ishyamba rya Zika ryo muri Uganda, aho yari yitaruye inkende ya rhesus. Mu myaka ibarirwa muri za mirongo, virusi ya Zika yari gake cyane kandi yagarukiraga ku bantu rimwe na rimwe muri Afurika no muri Aziya, aho usanga indwara nyinshi zitera ibimenyetso byoroheje cyangwa nta bimenyetso. Icyakora, mu 2015, icyorezo kinini cyabaye muri Berezile, cyahise gikwira mu bindi bihugu byo muri Amerika y'Epfo, Karayibe, ndetse no hanze yacyo, bikurura isi yose.

Ibimenyetso byanduye virusi ya Zika mubisanzwe biroroshye kandi birashobora kuba birimo umuriro, guhubuka, kubabara ingingo, kubabara imitsi, kubabara umutwe, na conjunctivitis. Ibi bimenyetso mubisanzwe bigaragara iminsi 2 kugeza kuri 7 nyuma yo kurumwa numubu wanduye bikamara iminsi 2 kugeza 7. Mu gihe abantu benshi bakira neza nta ngorane zikomeye, virusi ya Zika yagize uruhare mu ndwara zikomeye z’imitsi, cyane cyane microcephaly ku bana bavutse ku babyeyi banduye igihe batwite, na syndrome ya Guillain-Barré ku bantu bakuru.

Imbere y’iterabwoba rikomeje guterwa na arbovirus nka Zika, Chikungunya, na Dengue,IkizaminiYashyizeho urutonde rwibintu byateye imbere muri vitro yo kwisuzumisha (IVD), byerekana intambwe igaragara mu gusuzuma neza kandi byihuse izo ndwara. Izi reagent, zirimo Zika Virus Antibody IgG / IgM Ikizamini, ZIKA IgG / IgM / Chikungunya IgG / IgM Combo Ikizamini, hamwe na Dengue NS1 / Dengue IgG / IgM / Zika Virus IgG / IgM Combo, hamwe nibizamini bya Dengue NS1 / Dengue IgG / IgM / Zika gusuzuma indwara ya arbovirus.

Ikibazo gikomeye mugukemura izo arbovirus nuko ibimenyetso byabo byambere bisa cyane, akenshi biganisha ku gusuzuma nabi. Imbonerahamwe ikurikira iragaragaza ibimenyetso bisanzwe bya Zika, Dengue, na Chikungunya, hamwe namakuru yingenzi y’amavuriro, yerekana impamvu urujijo ruvuka:

* Hashingiwe ku bushakashatsi bwakozwe mu 2024 bw’indwara 1200 z’amavuriro mu turere dushyuha

** Harimo icyegeranyo cy'icyitegererezo, ubwikorezi, hamwe n'ibizamini bikurikirana

Bitewe nubu buryo bugaragara mubimenyetso byambere hamwe nigipimo kinini cyo kwisuzumisha nabi (kurenga 50% kuri virusi uko ari eshatu), biragoye cyane kubashinzwe ubuvuzi gutandukanya izo ndwara zishingiye gusa kubitekerezo byubuvuzi. Umwanya muremure usabwa kugirango wemeze hamwe n'ibizamini bimwe bikomeza gutinda kuvura no kurwanya indwara. Aha niho ibizamini byacu bishya bya combo biza gukina. Twisunze umusingi wibizamini byikarita imwe, twateje imbere amakarita menshi yo guhuza amakarita ashobora kwerekana indwara nyinshi mugupimisha kamwe, kugabanya igihe cyo kwisuzumisha kugera kuri 70% no kugabanya ibipimo byo kwisuzumisha nabi bikagera munsi ya 5% mubigeragezo byamavuriro.

Ikizamini cya virusi ya Zika IgG / IgM Ikizamini: Kumenya Indwara Zika hamwe na Precision

Ikizamini cya Zika Virus Antibody IgG / IgM ni immunoassay yihuta ya chromatografique yagenewe gutahura neza antibodiyite za IgG na IgM virusi ya Zika mumaraso yabantu yose, serumu, cyangwa plasma. Iki kizamini ni ubufasha bukomeye mugupima indwara zanduye Zika. Mugutahura ko antibodiyite zihari, abashinzwe ubuzima barashobora kumenya niba umurwayi aherutse kwandura (IgM positif) cyangwa yarahuye nacyo (IgG positif).

Ibyiza byibicuruzwa. Umwihariko wacyo (99.2%) ugabanya guhuza imbaraga hamwe na antibodies ziva muri flavivirusi zifitanye isano, zitanga ibisubizo byizewe. Byongeye kandi, ibikoresho byo kwipimisha byateguwe mugihe kirekire, hamwe nubuzima bwamezi 24 iyo bibitswe kuri 2-8 ° C, kugabanya imyanda no kwemeza kuboneka ahantu hitaruye hamwe n’ibikorwa remezo bikonje bikonje.

ZIKA IgG / IgM / Chikungunya IgG / IgM Ikizamini cya Combo: Gusuzuma kabiri kuri Arbovirus Bifitanye isano

Ikizamini cya ZIKA IgG / IgM / Chikungunya IgG / IgM Combo ni igikoresho cy’impinduramatwara cyemerera kumenya icyarimwe no gutandukanya immunoglobuline M (IgM) na antibodiyite immunoglobulin G (IgG) kuri virusi ya Zika na virusi ya Chikungunya. Chikungunya, kimwe na Zika, ni indwara iterwa n'umubu ishobora gutera ububabare bukabije bw'ingingo, umuriro, ndetse no guhubuka.

Ibyiza byibicuruzwa: Iki kizamini cya combo gikuraho ibikenewe byo kwipimisha bitandukanye kuri Zika na Chikungunya, bigabanya igihe cyo kwipimisha 50% ugereranije nibizamini bya buri muntu (kuva kumasaha 52 kugeza kuminota 20). Ikoresha uburyo bwihariye bwo gutahura imiyoboro ibiri itanga itandukaniro rigaragara hagati ya virusi zombi, hamwe n’igipimo cyambukiranya munsi ya 1%, ikirinda urujijo rushobora guturuka ku bimenyetso bisa n’ubuvuzi. Ikizamini gisaba kandi urugero ruto (5µL gusa), bigatuma byoroha kubarwayi, cyane cyane abana nabasaza.

Dengue NS1 / Dengue IgG / IgM / Zika Virus IgG / IgM Combo Ikizamini: Uburyo bwuzuye bwo gusuzuma Arbovirus

Ikizamini cya Dengue NS1 / Dengue IgG / IgM / Zika Virus IgG / IgM Combo ni igisubizo cyuzuye kitagaragaza gusa ko hari virusi ya Dengue binyuze mu gutahura antigen ya NS1, IgG, na IgM ariko ikanagaragaza virusi ya Zika IgG na antibodiya za IgM. Indwara ni ikibazo cy’ubuzima rusange mu turere twinshi dushyuha kandi dushyuha, bitera ibimenyetso byinshi kuva ku ndwara yoroheje y’ibicurane kugeza ibicurane bikabije kandi bishobora guhitana ubuzima bwa dengue hemorhagie.

Ibyiza byibicuruzwa: Kwinjiza antigen ya NS1 ituma hasuzumwa hakiri kare Dengue hakiri kare iminsi 1-2 nyuma yuko ibimenyetso bitangiye, hamwe na sensibilité ya 97.3% yo gutahura NS1, ikaba ari ingenzi cyane mu kuvura igihe kugirango hirindwe ibibazo bikomeye (bikura mu 10-20% by’imiti itavuwe). Ikizamini cyo kumenya ibintu byinshi (NS1, IgG, IgM kuri Dengue na IgG, IgM kuri Zika) gitanga umwirondoro wuzuye wo gusuzuma, ufasha abashinzwe ubuzima kumva icyiciro cyanduye no gufata ibyemezo byo kuvura neza. Byongeye kandi, ikizamini cyemejwe kugirango gikoreshwe mu mavuriro atandukanye, cyerekana imikorere ihamye muri laboratoire zitandukanye hamwe na coefficient de variable (CV) iri munsi ya 5%.

Dengue NS1 / Dengue IgG / IgM / Zika Virus IgG / IgM / Chikungunya Ikizamini: Igikoresho cyo Gusuzuma Ultimate Arbovirus

Ikizamini cya Dengue NS1 / Dengue IgG / IgM / Zika Virus IgG / IgM / Chikungunya gifata isuzuma rya arbovirus ku rundi rwego uhuza ubushobozi bwo gutahura ibizamini byose byabanjirije iki hanyuma ukongeraho no kumenya virusi ya Chikungunya IgG na antibodiya za IgM. Iki kizamini-muri-kimwe cyateguwe kugirango gitange isuzuma ryuzuye kandi ryuzuye ryindwara nyinshi za arbovirus mubisubizo bimwe.

Ibyiza byibicuruzwa. Igaragaza tekinoroji igezweho yo kongera ibimenyetso byongera ubushobozi bwo gutahura intego zose (impuzandengo ya 98.1% muri analyite zose), ikemeza ko n'indwara zo murwego rwo hasi zitabura. Ikizamini kandi kizana interineti-yorohereza abakoresha hamwe nubuyobozi busobanutse bwo gusobanura ibisubizo, byoroshye gukoresha no kubakozi bashinzwe ubuzima badafite uburambe, hamwe namahugurwa yamasaha 2 gusa asabwa kubumenyi.

Ibiranga ninyungu zaIkizamini IVD Kumenyekanisha

• Ibisubizo Byihuse: Ibi bizamini byose bitanga ibisubizo mugihe gito, mubisanzwe muminota 15, bituma hafatwa ibyemezo byihuse mugupima no kuvura abarwayi.
• Ibyiyumvo Byinshi kandi Byihariye. Ibi nibyingenzi mugusuzuma neza no gucunga neza abarwayi.
• Ubwoko bw'icyitegererezo cyoroshye: Zishobora gukoreshwa nubwoko butandukanye bwikitegererezo, harimo urutoki rwamaraso yose, amaraso yose yimitsi, serumu, na plasma, bigatuma bikoreshwa muburyo butandukanye bwamavuriro n’ubuvuzi.
• Kuborohereza gukoreshwa: Ibizamini biroroshye gukora kandi bisaba amahugurwa make, bigatuma bigera kubashinzwe ubuvuzi haba mubutunzi bukize kandi butagira amikoro make.
• Ibisubizo Intego.

Umwanzuro

Ikizaminiubwoko bushya bwa virusi ya IVD kuri virusi ya Zika, Chikungunya, na Dengue byerekana iterambere rikomeye mu bijyanye no gusuzuma arbovirus. Urebye ibimenyetso byinshi byerekana ibimenyetso hakiri kare hamwe nigipimo kinini cyo kwisuzumisha nabi (hejuru ya 50%) murizo ndwara, ibizamini byacu bya combo, byakozwe mubizamini byikarita imwe, bishobora gutahura indwara nyinshi icyarimwe hamwe nigipimo cyo kwisuzumisha nabi kiri munsi ya 5% nibihe byo kwisuzumisha munsi yiminota 20, bifite akamaro kanini. Hamwe nibyiza bidasanzwe byibicuruzwa birimo sensibilité yo hejuru, umwihariko, gukora neza, no koroshya imikoreshereze, izo reagent zashyizweho kugirango zongere zisobanure uburyo indwara ya arbovirus isuzumwa kandi igacungwa. Mu guha abashinzwe ubuvuzi ibikoresho nyabyo, byihuse, kandi byuzuye byo gusuzuma, izo reagent zifite ubushobozi bwo kuzamura umusaruro w’abarwayi, kongera igenzura ry’indwara, no kugira uruhare mu kurwanya neza icyorezo cya arbovirus. Mugihe isi yose yindwara ya arbovirus ikomeje kwiyongera, ibi bizamini bishya bigiye kugira uruhare runini mukurwanya ibyo byangiza ubuzima rusange.