Testsealabs Myoglobin/CK-MB/Troponin ⅠCombo Test

I-Myoglobin (MYO)

I-Myoglobin (MYO) iyi-heme-protein evame ukutholakala kumisipha yamathambo kanye nenhliziyo, enesisindo samangqamuzana angu-17.8 kDa. Yakha cishe u-2% wengqikithi yamaprotheni emisipha futhi inesibopho sokuthutha umoya-mpilo ngaphakathi kwamaseli emisipha.

Lapho amangqamuzana emisipha alimala, i-myoglobin idedelwa ngokushesha egazini ngenxa yobukhulu bayo obuncane. Ukulandela ukufa kwezicubu okuhambisana ne-myocardial infarction (MI), i-myoglobin ingenye yezimpawu zokuqala ezikhuphuka ngaphezu kwamazinga ajwayelekile:

• Inyuka ngokulinganiswa ngaphezu kwesisekelo phakathi kwamahora angu-2-4 ngemuva kwe-infarct.
• Ifinyelela inani eliphakeme amahora angama-9-12.
• Ibuyela kusisekelo phakathi kwamahora angama-24–36.

Imibiko eminingana iphakamisa izinsiza zokulinganisa i-myoglobin ekuqinisekiseni ukungabikho kwe-myocardial infarction, ngamavelu okubikezela amabi afika ku-100% abikwe ngezikhathi ezithile ngemva kokuqala kwezimpawu.

I-Creatine Kinase MB (CK-MB)

I-Creatine kinase MB (CK-MB) iyi-enzyme ekhona kumisipha yenhliziyo, enesisindo samangqamuzana angu-87.0 kDa. I-Creatine kinase iyi-molecule ye-dimeric eyakhiwe ngamayunithi amabili ("M" kanye "no-B"), ahlanganayo akhe ama-isoenzymes amathathu: CK-MM, CK-BB, kanye ne-CK-MB. I-CK-MB iyi-isoenzyme ebandakanyeka kakhulu kumetabolism yezicubu zemisipha yenhliziyo.

Ukulandela i-MI, ukukhululwa kwe-CK-MB egazini kungatholwa phakathi kwamahora angu-3-8 ngemva kokuqala kwezimpawu:

• Iphakama phakathi kwamahora angu-9-30.
• Ibuyela kusisekelo phakathi kwamahora angu-48–72.

I-CK-MB ingenye yezimpawu ezibaluleke kakhulu zenhliziyo futhi yaziwa kabanzi njengomaka wendabuko wokuxilonga i-MI.

I-Cardiac Troponin I (cTnI)

I-Cardiac troponin I (cTnI) iphrotheni etholakala kumisipha yenhliziyo, enesisindo samangqamuzana angama-22.5 kDa. Iyingxenye ye-complex subunit complex (kanye ne-troponin T ne-troponin C); kanye ne-tropomyosin, le nkimbinkimbi ilawula umsebenzi we-ATPase we-calcium-sensitive we-actomyosin emisipha yamathambo nenhliziyo.

Ngemuva kokulimala kwenhliziyo, i-troponin I ikhishwa egazini amahora angu-4-6 ngemva kokuqala kobuhlungu. Iphethini yayo yokukhululwa ifana ne-CK-MB, kodwa ngenkathi i-CK-MB ibuyela kokujwayelekile phakathi namahora angu-72, i-troponin I ihlala iphakanyisiwe izinsuku ezingu-6-10-ihlinzeka ngewindi elide lokuthola ukulimala kwenhliziyo.

I-cTnI inokucaciswa okuphezulu kokulimala kwe-myocardial, okuboniswa ezimeni ezifana nesikhathi sokuhlinzwa, ukugijima kwangemva kwemarathon, kanye nokuhlukumezeka kwesifuba okufiphele. Iphinde ikhishwe ezimeni zenhliziyo ngaphandle kwe-acute myocardial infarction (AMI), njenge-angina engazinzile, ukwehluleka kwenhliziyo eqinile, nokulimala kwe-ischemic kusuka ekuhlinzweni kwe-coronary artery bypass. Ngenxa yokucaciswa kwayo okuphezulu nokuzwela kwezicubu ze-myocardial, i-troponin I manje isiyi-biomarker ekhethwa kakhulu ye-MI.

I-Myoglobin/CK-MB/Troponin Ⅰ Combo Test

I-Myoglobin/CK-MB/Troponin Ⅰ Combo Test isivivinyo esilula esisebenzisa inhlanganisela yezinhlayiya ezinamasosha omzimba e-MYO/CK-MB/cTnI futhi sithwebule ama-reagents ukuze kutholwe ngokukhethekile i-MYO, CK-MB, ne-cTnI egazini lonke, i-serum, noma i-plasma.