Thola Isixazululo Esisheshayo Sokuthola Izifo Zokuphefumula

Izindlela Zesayensi Zokuhluka Kwe-Pathogen Yokuphefumula kanye Nobuchwepheshe Bokuxilonga Okuthuthukile

Ngokushintsha kwesimo sezulu kanye nokuhlukahluka kwe-pathogen, izehlakalo eziphezulu zezifo zokuphefumula sekuyinsakavukela.Umkhuhlane,I-COVID 19, ukutheleleka kwe-mycoplasmas, nezinye izifo ngokuvamile ziholela ekudidekeni komphakathi “ekuzihloleni kwakho” ngenxa yezimpawu ezigqagqene. Singazihlukanisa kanjani ngokushesha izimbangela zokugula? Ubuchwepheshe bokuthola inoveli bukuvumela kanjani ukwelashwa okunembayo? Lesi sihloko sihlanganisa imininingwane evela kochwepheshe bezokwelapha kanye namathrendi akamuva omkhiqizo ukuze kuhlaziywe amasu esayensi okulawula izifo zokuphefumula.

Ungehlukanisa Kanjani Ngokwesayensi Phakathi Kwezimpawu Ezifanayo?

Umkhuhlane, i-COVID-19, izifo ze-mycoplasma, futhi umkhuhlane ovamile uhambisana nemfiva, ukukhwehlela, nokukhathala, kodwa umehluko ocashile ungasiza ekuhloleni kokuqala:

• Umkhuhlane: Ukuqala kakhulu, ukushisa okuphezulu (>38.5°C), okuhambisana nobuhlungu bekhanda, ubuhlungu bemisipha, nokukhathala okukhulu.
• I-COVID 19: Imfiva engase ilahlekelwe iphunga/ukunambitheka, ukukhwehlela okomile okuqhubekayo, kanye nengozi ephezulu yenyumoniya ezimeni ezinzima.
• I-Mycoplasma Infection: Ukukhwehlela okomile okuqhubekayo, okuvame kakhulu ezinganeni; umkhuhlane omncane kodwa inkambo ende (amasonto).
• Umkhuhlane Ovamile: Izimpawu ezimaphakathi njengokuminyana kwekhala/ikhala eligijimayo, okungavamile ukuba nomkhuhlane ophezulu noma ukungaphatheki kahle kwesistimu.

Nokho, izimpawu zomtholampilo zizodwa azikwazi ukuqinisekisa ukuxilonga. UDkt. Wang Guiqiang, uMqondisi Wezifo Ezithathelwanayo esibhedlela sasePeking University First, uyakugcizelela lokhoukuhlolwa kwe-etiological kubalulekile, ikakhulukazi emaqenjini asengozini enkulu (isb, asebekhulile, iziguli zezifo ezingapheli).

Rapid Diagnostic Technologies: From Empirical Guesswork to Precision Medicine

Ukubhekana nezingozi zokutheleleka ngegciwane kanye nokuhlangabezana nezidingo zokuxilongwa ngesikhathi,ukutholwa kwe-multiplex pathogenkuvele njengoshintsho lomdlalo. Ukuqanjwa kwamanje kokuhlola okusheshayo manje sekumboza inqwaba yamagciwane okuphefumula:

Ukuhlola Okubalulekile Kwe-Pathogen-Specific

1. Ukuhlolwa komkhuhlane we-A/B
2. Ukuhlolwa kwe-SARS-CoV-2 (COVID-19).
3. Ukuhlolwa kwe-Mycoplasma pneumoniae
4. I-Legionella pneumophila Test(ihlonza isifo se-Legionnaires, imbangela ye-pneumonia enzima)
5. Ukuhlolwa kwe-Chlamydia pneumoniae(ukutholwa kwe-pneumonia okungavamile)
6. Ukuhlolwa kwe-TB (Tuberculosis).(kubalulekile ekuhlonzweni kwe-TB kusenesikhathi)
7. Strep A Test(ukuhlolwa kwe-Group A streptococcal pharyngitis)
8. Ukuhlolwa kwe-RSV (Respiratory Syncytial Virus)(okuvamile ezinganeni nakubantu abadala)
9. Ukuhlolwa kwe-Adenovirus(okuxhunyaniswa nezifo ezinzima zokuphefumula/i-ocular)
10. Ukuhlolwa kwe-Human Metapneumovirus (HMPv).(ulingisa izimpawu ze-RSV)
11. I-Malaria Ag Pf/Pan Test(uhlukanisa izimuncagazi zikamalaleveva ezindaweni ezihlala kuzo)

I-Multiplex Assays Yokuhlola Okuphelele

• Amaphaneli e-Quadriplex: Umkhuhlane A/B + COVID-19 + RSV
• Inyumoniya Panel: I-Mycoplasma + Chlamydia + Legionella + Adenovirus
• Ukuhlolwa kwe-Combo Kwezingane: I-RSV + HMPv + Strep A
• Amakhithi Wesifunda Esishisayo: Umalaleveva + Udenga + I-Typhoid (ikheli eligqagqene izimpawu ze-febrile)

Lokhu kuhlola kuletha imiphumela emizuzwini eyi-15–30 kusetshenziswa i-PCR, i-antigen-detection, noma amapulatifomu asekelwe ku-CRISPR, okwenza odokotela bakwazi:

• Khipha izimbangela zebhaktheriya ngokumelene negciwane
• Gwema ukusebenzisa kabi ama-antibiotic
• Qalisa amakhambi ahlosiwe (isb, ama-antiviral omkhuhlane, ama-macrolides e-mycoplasma)

Indlela yegolide ye-immune colloidal inikeza isixazululo esithuthukisiwe sokutholwa okusheshayo nokuthembekile kwezifo zokuphefumula. Le ndlela entsha iphumelela kakhulu ekuhlonzeni amagciwane afana namagciwane omkhuhlane, i-adenoviruses, amagciwane e-respiratory syncytial virus (RSV), kanye ne-human metapneumovirus (HMPV), inika amandla ochwepheshe bezokunakekelwa kwempilo ukuthi basebenzise ukungenelela okufika ngesikhathi. Isibonelo, izifundo zemitholampilo zigqamisa ukunemba kwayo okumangazayo, kuzuza ama-93% ekutholweni komkhuhlane A uma kuqhathaniswa nesiko legciwane. Amathuluzi okuxilonga afana neUkuhlolwa kwe-FLU A/B, Ukuhlolwa kwe-COVID-19, Ukuhlolwa kwe-HMPV, Ukuhlolwa kwe-RSV, futhiUkuhlolwa kwe-Adenokukhombisa ukuguquguquka kwayo ekubhekaneni nezinselele eziningi zokuphefumula. Ngokuvumela ukuxilongwa kusenesikhathi, le nqubo ithuthukisa kakhulu imiphumela yesiguli futhi isiza ekuvimbeleni ukusakazeka kwezifo.

Okuthathwayo Okubalulekile

• Indlela yegolide ye-immune colloidal ithola izifo zamaphaphu ngokushesha. Lokhu kusiza odokotela benze ngokushesha.
• Kulula ukuyisebenzisa futhi idinga ukuqeqeshwa okuncane. Lokhu kwenza kube kuhle ezindaweni eziningi zokunakekelwa kwempilo.
• Imiphumela yokuhlolwa ivela emaminithini. Lokhu kusiza ekuxilongeni ngokushesha kanye nokwelashwa.
• Lezi zivivinyo zishibhile futhi zihlala isikhathi eside. Lokhu kwenza kube lula ukuthi abantu bathole.
• Amakhithi okuhlola asekhaya avumela abantu ukuthi bahlole impilo yabo kusenesikhathi. Bangathola izifo ngokushesha.

Ukuqonda i-Immune Colloidal Gold Technique

Incazelo kanye Nezimiso Eziwumgogodla

I-immune colloidal gold technique iyindlela yokuxilonga esebenzisa izici eziyingqayizivele zezinhlayiya zegolide eli-colloidal ukuthola ama-antigen athile noma amasosha omzimba kumasampuli ebhayoloji. Le nqubo isebenza ngomgomo we-immunochromatography, lapho ama-nanoparticles egolide ahlanganiswe namasosha omzimba e-monoclonal ebophezela kuma-analyte aqondiwe, enze imigqa ebonakalayo emgqeni wokuhlola. Imiphumela ebonakalayo ivumela ochwepheshe bezempilo ukuthi babone ngokushesha ukuba khona kwamagciwane.

Ithiphu: Izinhlayiya zegolide ze-Colloidal zizinzile kakhulu futhi zibonisa izici ezinhle kakhulu zokubona, ezizenza zilungele ukusetshenziswa kokuxilonga.

Ucwaningo lokuthuthukiswa kwemicu yokuhlola ye-colloidal gold immunochromatographic ukuze kutholwe ubusheleleziUBrucellaibonise ukucaciswa okuphezulu kwesu. Amasosha omzimba e-Monoclonal aqondise i-lipopolysaccharides (LPS) aqinisekise ukutholwa okunembile, kuyilapho ukuhlolwa kwe-lateral flow immunochromatographic (LFIT) kubonise umkhawulo ophansi wokutholwa uma kuqhathaniswa namanye amakhithi. Lokhu okutholakele kugqamisa ukuqina kwenqubo yegolide ye-immune colloidal ekuletheni imiphumela enembayo kuzo zonke izimo zokuxilonga ezihlukahlukene.

Kungani Isebenza Ezifweni Zokuphefumula

Indlela yegolide ye-immune colloidal iphumelela kakhulu ekuhlonzeni izifo zokuphefumula ngenxa yamandla ayo okubona ngokushesha kanye nokuvumelana nezimo kumagciwane ahlukahlukene. Ikhono layo lokuhlinzeka ngemiphumela phakathi namaminithi lilenza libe yigugu phakathi nomsebenzi omningi weziguli eziphuma ngaphandle, ikakhulukazi ezilungiselelweni zomtholampilo lapho ukungenelela okufika ngesikhathi kubalulekile.

Ucwaningo oluyisibonelo oluhlaziya amagciwane okuphefumula ezinganeni lwembula ukuthi izifo zemigudu yokuphefumula ephezulu zazivamile, ukusuleleka okuhlangene kwandisa ingozi yenyumoniya enzima. Ukuhlolwa kwegolide le-Colloidal kubonakale kusebenza ngempumelelo ekuhlolweni okusheshayo, okuvumela abahlinzeki bezokunakekelwa kwempilo ukuthi babone izifo kusenesikhathi futhi kwehlise umthwalo ezikhungweni zokuxilonga. Nakuba ukuzwela kwalokhu kuhlola kungase kungafani nezindlela ze-PCR, isivinini sazo kanye nokusebenziseka kalula kwazo kuzenza kube ukukhetha okungokoqobo kokuhlola kokuqala.

Ucwaningo lokuqhathanisa luphinde lugcizelele izinzuzo zokuhlolwa kwegolide kwe-immune colloidal ngaphezu kwezindlela zokuxilonga. Lezi zivivinyo zinikeza ukuzwela okuphezulu nokucaciswa, okuqinisekisa ukutholwa okunembile kwabahlaziyi abaqondiwe. Idizayini yabo esebenziseka kalula idinga ukuqeqeshwa okuncane, okubenza bafanelekele izindawo ezihlukahlukene zokunakekelwa kwezempilo. Ukwengeza, ukusebenza kahle kwezindleko nempilo yeshelufu ende kuthuthukisa ukufinyeleleka kwabo bobabili abahlinzeki neziguli.

Inhlanganisela yendlela yegolide ye-immune colloidal yejubane, ukunemba, kanye nokufinyeleleka kwayo iyenza ibe ithuluzi elinamandla lokubhekana nezifo zokuphefumula. Ukuguquguquka kwayo kuqinisekisa ukuthi ingasetshenziswa ezinhlobonhlobo ezibanzi zamagciwane, okusekela ukuxilongwa kusenesikhathi kanye namasu okwelapha asebenzayo.

Isinyathelo Ngesinyathelo Umhlahlandlela Wokusebenzisa I-Immune Colloidal Gold Technique

Ukulungiselela Nezinto Ezidingekayo

Ukulungiselela kahle kubalulekile ekusetshenzisweni ngempumelelo kwe-immune colloidal gold technique. Le nqubo ihilela ukuhlanganisa izingxenye ezithile eziqinisekisa imiphumela enembile nethembekile. Into ngayinye idlala indima ebalulekile ekuhambeni komsebenzi okuxilonga, kusukela ekuhlungeni isampula kuya ekutholweni kwe-antigen.

Ukuze kulungiswe ikhambi legolide le-colloidal, abacwaningi batusa ukulungisa i-pH ibe ngu-7.4 kusetshenziswa i-potassium carbonate ukuze kube nokuzinza okuphelele. Ukugxila kwamasosha omzimba kufanele kulinganiswe ngokucophelela ukuze kufinyelelwe ukuhlangana okusebenzayo kwe-immunological. Isibonelo, ukungeza u-60 µg wokuthola amasosha omzimba ahlanzekile ku-10 ml wesixazululo segolide eli-colloidal kuqinisekisa ukukhangiswa okuqinile. Ukuhlanganiswa kokugcina kwe-immune strip kufanele kwenzeke ezimeni ezinomswakama omncane ukuze kunwetshwe isikhathi sokugcina.

Izindlela Zokuqoqwa Kwesampula

Ukuqoqwa kwesampula okunembile kubalulekile ukuze uthole imiphumela ethembekile. Amasampula ebhayoloji, afana nama-nasal swabs, ama-swabs omphimbo, noma igazi, avame ukusetshenziswa kuye nge-pathogen eqondiwe. Ochwepheshe bezokunakekelwa kwempilo kumele balandele izivumelwano ezijwayelekile ukuze baqinisekise ubuqotho besampula.

Ezifweni zokuphefumula, ama-nasal swabs avame ukuthandwa ngenxa yekhono lawo lokuthatha izinhlayiya zegciwane emgudwini wokuphefumula ophezulu. I-swab kufanele ifakwe ngobumnene ekhaleni futhi ijikelezwe izikhathi eziningana ukuze iqoqe izinto ezanele. Amasampula egazi, ngakolunye uhlangothi, alungele ukuthola amasosha omzimba, ikakhulukazi ezimeni lapho izimpendulo zamasosha omzimba ziqashwe ngeso lokhozi.

Qaphela: Ukulebula okufanele nokugcinwa kwamasampula kubalulekile ukuze kuvinjelwe ukungcoliswa nokuqinisekisa ukuhlolwa okunembile.

Ukusebenzisa Ukuhlolwa

Indlela yegolide ye-immune colloidal isebenzisa inqubo eqondile yokufaka isicelo, iyenze ifinyeleleke kubo bobabili ochwepheshe bezokwelapha kanye nabantu abenza izivivinyo zasekhaya. Umugqa wokuhlola uklanyelwe ukuthola ama-antigen athile noma amasosha omzimba ngamabhande abonakalayo avela emigqeni yokuthola.

Ukuze benze uhlolo, abasebenzisi kufanele basebenzise isampula kuphedi ekhethiwe futhi bavumele uketshezi ukuthi lugeleze emgqeni. Emaminithini ambalwa, imiphumela ibonakala, kube nemiphumela emihle ekhonjiswa amabhande ahlukene emigqeni yokuhlola. Ucwaningo olulawulwayo lukhombisile ukuthi le ndlela ifinyelela ukuzwela okuphezulu nokucacisa, okwenza kube ukukhetha okuthembekile ukuthola amagciwane afanaI-Toxoplasma gondii.

Ithiphu: Qinisekisa ukuthi umugqa wokuhlola uhlala uzinzile phakathi nenqubo ukuze ugweme amaphutha abangelwa izici zangaphandle ezifana nomswakamo noma ukushintshashintsha kwezinga lokushisa.

I-immune colloidal gold technique yenza izinqubo zokuxilonga zibe lula kuyilapho igcina ukunemba nokusebenza kahle. Inqubo yayo yokufaka isicelo esheshayo isekela ukuthathwa kwezinqumo ngesikhathi, ikakhulukazi ezilungiselelweni zomtholampilo lapho isivinini sibalulekile.

Ukutolika Imiphumela

Ukuchazwa okunembile kwemiphumela kubalulekile ukuze kusetshenziswe indlela yegolide ye-immune colloidal ngokuphumelelayo. Amabhendi abonakalayo emgqeni wokuhlola ahlinzeka ngezinkomba eziqondile zokuba khona noma ukungabikho kwama-antigen okuhlosiwe noma amasosha omzimba. Ochwepheshe bezokunakekelwa kwempilo kanye nabasebenzisi kufanele baqonde ukubaluleka kwalawa mabhendi ukuze benze izinqumo ezinolwazi.

Izinkomba Ezibalulekile Emgqeni Wokuhlola

Uhlu lokuhlola ngokuvamile lubonisa izindawo ezintathu ezihlukene:

1. Ulayini Wokulawula: Lo mugqa uqinisekisa ukufaneleka kokuhlolwa. Ukubukeka kwayo kubonisa ukuthi umugqa wokuhlola usebenze ngendlela efanele futhi isampula ligeleza njengoba bekuhlosiwe.
2. Umugqa Wokuhlola: Ibhendi ebonakalayo kule zoni isho umphumela omuhle, obonisa ukuba khona kwe-antigen eqondiwe noma i-antibody.
3. Indawo Engenalutho: Ukungabikho kwanoma yimaphi amabhendi kule ndawo kuphakamisa umphumela ongemuhle, okusho ukuthi umhlaziyi okuqondiwe akatholwanga.

Qaphela: Uma ulayini wokulawula wehluleka ukuvela, ukuhlola akuvumelekile futhi kufanele kuphindwe ngomugqa omusha.

Izinyathelo Zokuhlaziywa Kwemiphumela

Ukutolika imiphumela kuhilela indlela ehlelekile yokuqinisekisa ukunemba:

• Isinyathelo 1: Qinisekisa ukubukeka komugqa wokulawula.
• Isinyathelo sesi-2: Hlola umugqa wokuhlola ukuze uthole amabhendi abonakalayo.
• Isinyathelo sesi-3: Qhathanisa ukushuba komugqa wokuhlola namazinga ereferensi, uma ekhona.
• Isinyathelo sesi-4: Rekhoda okutholakele bese uthintana nokuxilongwa
  

  Amacebiso Awusizo Okuhumusha Okunokwethenjelwa

  • Izimo zokukhanyisa: Yenza ukuhlaziya ngaphansi kokukhanya okwanele ukuze ugweme ukufunda kabi amabhendi afiphele.
  • Isikhathi: Hlola imiphumela phakathi nesikhathi esinconyiwe ukuze uqinisekise ukunemba.
  • Amadokhumenti: Rekhoda imiphumela ngokushesha ukuze ugcine umlando ocacile wokuxilonga.

  Indlela yegolide ye-immune colloidal yenza incazelo yemiphumela ibe lula ngefomethi yayo ebonakalayo. Idizayini yayo esebenziseka kalula iqinisekisa ukufinyeleleka kwabo bobabili ochwepheshe bezokwelapha kanye nabantu abenza ukuhlolwa ekhaya. Ngokulandela amaphrothokholi ajwayelekile, abasebenzisi bangafinyelela imiphumela ethembekile esekela ukungenelela kwezokwelapha okufika ngesikhathi.

  Izinzuzo kanye nemikhawulo ye-Immune Colloidal Gold Technique

  Izinzuzo Eziyinhloko Zokuthola Ngokushesha

  Indlela yegolide ye-immune colloidal inikezela ngezinzuzo ezimbalwa eziyenza ibe yinketho ekhethwayo yokuxilonga ngokushesha. Ikhono layo lokuletha imiphumela ngokushesha libaluleke kakhulu kuzilungiselelo zomtholampilo nezindawo zokunakekela. Le ndlela ifakazele ukuthi iyasebenza ekutholeni amasosha omzimba aphikisana ne-SARS-CoV-2, okuvumela ukungenelela okufika ngesikhathi ngesikhathi sokuqubuka kwezifo.

  Izinzuzo ezibalulekile zifaka:

  • Ukusebenza kahle kwezindleko uma kuqhathaniswa nokuhlolwa okusekelwe elabhorethri.
  • Idizayini esebenziseka kalula, ilungele ochwepheshe bezokunakekelwa kwempilo kanye nabantu abanokuqeqeshwa okuncane.
  • Ukusetshenziswa okuphezulu ezindaweni ezinezinsiza eziphansi, lapho amathuluzi okuxilonga athuthukile angase angatholakali.
  • Ukusebenza ekugadweni kwe-seroprevalence, ukusiza izinqubomgomo zezempilo zomphakathi.

  Lezi zici zenza indlela yegolide ye-immune colloidal ibe ithuluzi eliguquguqukayo lokubhekana nezinselele zokuxilonga ezimeni ezihlukahlukene zokunakekelwa kwezempilo. Amandla ayo okubona ngokushesha aqinisekisa ukuthi abahlinzeki bezokunakekelwa kwempilo bangathatha isinyathelo ngokushesha, bathuthukise imiphumela yesiguli futhi banciphise ukusabalala kwezifo ezithathelwanayo.

  Imikhawulo Evamile Nezinselele

  Naphezu kwezinzuzo zayo, inqubo yegolide ye-immune colloidal ibhekana nezinselele ezithile ezingaba nomthelela ekusebenzeni kwayo. Ucwaningo lokuqhathanisa luqokomisa ukuthi nakuba le ndlela inikeza imiphumela esheshayo, ingase intule ukuzwela kwamasu okuxilonga amangqamuzana.tic imihlahlandlela yokwenza okwengeziwe.

Izimo Ezivamile Nemiphumela Yazo

Izinselelo zobuchwepheshe nazo ziyavela ngesikhathi sokuqaliswa. Ama-nanoparticles asetshenziswe ku-assay angaphazamisa ukufundwa kwe-optical density, okuholela ekuhlukeni kwemiphumela. Ukwengeza, ukukhetha komklamo wokuhlola kudlala indima ebalulekile ekuqinisekiseni ukunemba. Isibonelo, ukuhlolwa kwe-in vitro kumele kulingise eduze izimo zempilo yangempela ukuze kunikeze imiphumela ethembekile.

Nakuba le mikhawulo ikhona, intuthuko eqhubekayo ekwakhiweni kokuhlola kanye nobuchwepheshe be-nanoparticle ihlose ukubhekana nalezi zinselele. Ngokucwenga lezi zici, indlela yegolide ye-immune colloidal ingaqhubeka nokusebenza njengethuluzi elithembekile nelisebenzayo lokuxilonga.

Ukusetshenziswa Okungokoqobo Kwesu Lokusebenza Kwegolide Le-Immune Colloidal

Sebenzisa kokuthi Izilungiselelo Zomtholampilo

Indlela yegolide ye-immune colloidal isiphenduke isisekelo ekuxilongweni komtholampilo ngenxa yejubane nokuthembeka kwayo. Izibhedlela namalabhorethri kuvame ukusebenzisa le ndlela ukuthola amagciwane okuphefumula afana namagciwane omkhuhlane, amagciwane e-respiratory syncytial virus (RSV), kanye ne-SARS-CoV-2. Isikhathi sayo sokushintsha ngokushesha sivumela abahlinzeki bezokunakekelwa kwempilo ukuthi benze izinqumo ezifika ngesikhathi, ikakhulukazi ngesikhathi sokuqubuka kwezifo noma umthamo omkhulu weziguli.

Eminyango yezimo eziphuthumayo, le nqubo isekela ukuhlolwa okusheshayo ngokuhlonza izifo phakathi nemizuzu. Ngokwesibonelo, ngesikhathi sokukhulelwaI-COVID 19ubhubhane, abasebenzi bezempilo bathembele ekuhlolweni kwegolide le-immune colloidal ukuhlola iziguli ngokuphumelelayo. Ubulula bedizayini yokuhlola kunciphisa isidingo sokuqeqeshwa okukhethekile, okwenza kufinyeleleke kubasebenzi bezokwelapha abahlukahlukene.

Ukwengeza, le ndlela ibonakala iwusizo kakhulu kuzilungiselelo ezinomkhawulo wezinsiza. Imitholampilo esezindaweni zasemakhaya noma ezinganakiwe iyazuza ekuphathekeni kwayo nasekuthengeni kwayo. Ngokungafani namathuluzi okuxilonga amangqamuzana, adinga imishini ethuthukisiwe, inqubo yegolide ye-immune colloidal isebenza ngokuphumelelayo nengqalasizinda encane. Lokhu kuzivumelanisa nezimo kuqinisekisa ukuthi ngisho nezikhungo zokunakekelwa kwezempilo ezikude zingahlinzeka ngokuxilongwa okunembile nangesikhathi.

Izimo Zokuhlola Ekhaya

Indlela yegolide ye-immune colloidal iphinde yazuza amandla ekuhlolweni kwasekhaya, inika abantu indlela elula yokuqapha impilo yabo. Izinsiza zokuzihlola eziklanywe ngale ndlela zivumela abasebenzisi ukuthi bathole amasosha omzimba noma ama-antigen ngaphandle kokuvakashela isikhungo sezempilo. Le ndlela inika abantu amandla okuthatha izinyathelo ezisheshayo ekulawuleni impilo yabo ngenkathi behlisa umthwalo wezinhlelo zezokwelapha.

Ucwaningo lugqamisa ukuba nokwenzeka nokunemba kwalezi zivivinyo kuzilungiselelo zasekhaya. Isibonelo, ucwaningo lubika ukuzwela okuphezulu kanye namazinga athile okuthola amasosha omzimba e-IgG ne-IgM. Abahlanganyeli kulolu cwaningo babonise ikhono lokuqeda izivivinyo bengagadiwe, futhi ngaphezu kuka-90% babike imiphumela evumelekile. Ithebula elilandelayo lifinyeza okutholakele okubalulekile:

Lokhu okutholakele kugcizelela ukusebenza kokuhlolwa kwegolide kwe-immune colloidal ukusetshenziswa ekhaya. Idizayini yabo eqondile iqinisekisa ukusetshenziswa kalula, ngisho nakubantu abangaqeqeshwanga kwezokwelashwa. Ngokuvumela ukutholakala kwezifo kusenesikhathi, lokhu kuhlola kunomthelela emiphumeleni yezempilo engcono futhi kusize ukunqanda ukusakazeka kwezifo.

Indlela yegolide ye-immune colloidal iguqule izindlela zokuxilonga ngesivinini sayo, ubulula, nokuvumelana nezimo. Ikhono layo lokuletha imiphumela esheshayo liyenza ibaluleke kakhulu ekutholeni izifo zokuphefumula emitholampilo nasemakhaya. Imibiko yokuhlaziya igqamisa imvelo yayo esebenziseka kalula, nakuba ukuhlukahluka ekusebenzeni kokuhlola kuwo wonke amakhithi ahlukene kugcizelela isidingo sokukhetha ngokucophelela. Isibonelo, amazinga okutholwa kwamasosha omzimba ezimeni ze-TB yamaphaphu ezingenayo amagciwane asukela ku-19.0% ukuya ku-42.5%, okubonisa amandla ayo ezimweni zokuxilonga eziyinselele.

Le nqubo inika amandla abahlinzeki bezempilo kanye nabantu ukuthi bathathe isinyathelo ngokushesha, bathuthukise imiphumela yesiguli futhi banqande ukusakazeka kwezifo. Ukufinyeleleka kwayo nokusebenza kahle kwayo kuyenza ibe ithuluzi elibalulekile lokuhlola izifo zesimanje.

FAQ

Iyini inqubo yegolide ye-immune colloidal esetshenziselwa?

Indlela yegolide ye-immune colloidal ithola ama-antigen noma amasosha omzimba kumasampula ebhayoloji. Isetshenziswa kabanzi ekuxilongeni izifo zokuphefumula,kufaka phakathi umkhuhlane, i-RSV, kanye ne-SARS-CoV-2, ngenxa yemiphumela esheshayo kanye nokucaciswa okuphezulu.

Ingabe kunembe kangakanani ukuhlolwa kwegolide le-immune colloidal?

Lezi zivivinyo zibonisa ukuzwela okuphezulu kanye nokucacisa, okuvamise ukudlula ama-90% kumagciwane amaningi. Ukuthembeka kwabo kubenza bafanelekele ukusetshenziswa emtholampilo nasekhaya, ikakhulukazi ekuhlolweni kokuqala.

Ingabe abantu bangakwazi ukuhlola igolide le-immune colloidal ekhaya?

Yebo, amakhithi okuhlola ekhaya ayatholakala. Lawa makhithi asebenziseka kalula futhi adinga ukuqeqeshwa okuncane, okuvumela abantu ukuthi baqaphe impilo yabo kalula futhi babone izifo kusenesikhathi.

Kuthatha isikhathi esingakanani ukuthola imiphumela yalezi zivivinyo?

Ukuhlolwa kwegolide le-colloidal amasosha omzimba kunikeza imiphumela phakathi nemizuzu. Lesi sikhathi sokushintsha ngokushesha sisekela ukuthathwa kwezinqumo ngesikhathi kuzo zombili izilungiselelo zomtholampilo nezomuntu siqu.

Ingabe ukuhlolwa kwegolide kwe-immune colloidal kuyabiza?

Lezi zivivinyo zithengeka kakhulu kunezindlela zokuxilonga zamangqamuzana. Izindleko zabo eziphansi nempilo ende yeshelufu zibenza bafinyeleleke kubahlinzeki bezempilo neziguli ezindaweni ezihlukahlukene.