Testsealabs COT Cotinine hoao
ʻO Cotinine ka metabolite mua o ka nicotine, kahi alkaloid ʻawaʻawa e hoʻoulu ai i ka ganglia autonomic a me ka ʻōnaehana nūnū waena i loko o ke kanaka.
He lāʻau lapaʻau ʻo Nicotine kahi e ʻike ʻia ai nā lālā a pau o ka hui puhi paka, inā ma o ka hoʻopili pololei ʻana a i ʻole ka inhalation ʻelua. Ma waho aʻe o ka paka, loaʻa pū ka nicotine ma ke ʻano he mea hoʻoikaika i ka puhi ʻana i nā lāʻau lapaʻau e like me ka nicotine gum, transdermal patch, a me nā nasal sprays.
I loko o kahi hōʻailona mimi 24-hola, ma kahi o 5% o ka nui nicotine i hoʻokuʻu ʻia e like me ka lāʻau i hoʻololi ʻole ʻia, me 10% ma ke ʻano he cotinine a me 35% ma ke ʻano he hydroxyl cotinine; Ua manaʻo ʻia ka ʻike ʻana o nā metabolites ʻē aʻe ma lalo o 5%.
ʻOiai ua manaʻo ʻia ʻo cotinine he metabolite hana ʻole, ʻoi aku ka paʻa o kona hoʻopau ʻana ma mua o ka nicotine, ʻo ia ka nui o ka urine pH hilinaʻi. ʻO ka hopena, ua manaʻo ʻia ka cotinine he māka olaola maikaʻi no ka hoʻoholo ʻana i ka hoʻohana ʻana i ka nicotine.
ʻO ka hapalua o ke ola o ka nicotine ma kahi o 60 mau minuke ma hope o ka inhalation a i ʻole ka lawelawe makua. Hoʻopau koke ʻia ka nikotine a me ka cotinine e ka puʻupaʻa; ʻO ka puka makani o ka ʻike ʻana i ka cotinine i loko o ka mimi ma kahi pae ʻoki ʻia o 200 ng/mL e manaʻo ʻia e piʻi i ka 2-3 mau lā ma hope o ka hoʻohana ʻana i ka nicotine.
Hāʻawi ka COT Cotinine Test (Urine) i kahi hopena maikaʻi ke ʻoi aku ka cotinine i loko o ka mimi ma mua o 200 ng/mL.

