Testsealabs Myoglobin/CK-MB/Troponin ⅠHoʻāʻo Combo

Myoglobin (MYO)

ʻO ka Myoglobin (MYO) he heme-protein i loaʻa maʻamau i ka ʻiʻo iwi iwi a me ka puʻuwai puʻuwai, me ke kaumaha molekala o 17.8 kDa. Aia ia ma kahi o 2% o ka nui o ka protein muscle a nona ke kuleana no ka lawe ʻana i ka oxygen i loko o nā ʻiʻo ʻiʻo.

Ke poino nā ʻiʻo, hoʻokuʻu koke ʻia ka myoglobin i loko o ke koko ma muli o kona liʻiliʻi. Ma hope o ka make ʻana o ke kino e pili ana me ka myocardial infarction (MI), ʻo ka myoglobin kekahi o nā māka mua e piʻi aʻe ma luna o nā pae maʻamau:

• Hoʻonui nui ʻia ma luna o ka palena i loko o 2-4 mau hola ma hope o ka infarct.
• Loaʻa i nā hola 9-12.
• E hoʻi i ka papa kuhikuhi i loko o 24-36 mau hola.

Manaʻo kekahi mau hōʻike e kōkua ana ke ana myoglobin i ka hōʻoia ʻana i ka nele o ka myocardial infarction, me nā waiwai wānana maikaʻi ʻole a hiki i ka 100% i hōʻike ʻia i nā manawa kikoʻī ma hope o ka hoʻomaka ʻana o ka hōʻailona.

Creatine Kinase MB (CK-MB)

ʻO Creatine kinase MB (CK-MB) he enzyme i loaʻa i loko o ka ʻiʻo puʻuwai, me ke kaumaha molekala o 87.0 kDa. ʻO Creatine kinase kahi mole dimeric i hana ʻia mai ʻelua mau ʻāpana ("M" a me "B"), i hui pū ʻia e hana i ʻekolu isoenzymes: CK-MM, CK-BB, a me CK-MB. ʻO CK-MB ka isoenzyme i komo nui i ka metabolism o ka ʻiʻo ʻiʻo puʻuwai.

Ma hope o MI, hiki ke ʻike ʻia ka hoʻokuʻu ʻana o CK-MB i ke koko i loko o 3-8 mau hola ma hope o ka hoʻomaka ʻana o ka hōʻailona:

• Loaʻa nā kiʻekiʻe i loko o 9-30 mau hola.
• E hoʻi i ka papa kuhikuhi i loko o 48-72 hola.

ʻO CK-MB kekahi o nā hōʻailona puʻuwai koʻikoʻi a ʻike nui ʻia ʻo ia ka māka maʻamau no ka hōʻoia ʻana i ka MI.

ʻO Troponin I (cTnI)

ʻO ka cardiac troponin I (cTnI) he pūmua i loaʻa i loko o ka ʻiʻo puʻuwai, me ke kaumaha molekala o 22.5 kDa. He ʻāpana ia o kahi paʻakikī ʻekolu-subunit (me ka troponin T a me ka troponin C); me ka tropomyosin, hoʻoponopono kēia paʻakikī i ka hana ATPase koʻikoʻi calcium o actomyosin i loko o ka ʻiʻo iwi a me ka puʻuwai puʻuwai.

Ma hope o ka ʻeha puʻuwai, hoʻokuʻu ʻia ka troponin I i ke koko 4-6 mau hola ma hope o ka hoʻomaka ʻana o ka ʻeha. Ua like kona ʻano hoʻokuʻu me CK-MB, akā ʻoiai e hoʻi ana ʻo CK-MB i ka maʻamau i loko o 72 mau hola, hoʻokiʻekiʻe ʻia ka troponin I no nā lā 6-10-e hāʻawi ana i kahi puka aniani ʻike lōʻihi no ka ʻeha puʻuwai.

He kūlana kiʻekiʻe ka cTnI no ka pōʻino o ka myocardial, i hōʻike ʻia i nā kūlana e like me ka wā perioperative, ka holo ʻana ma hope o ka marathon, a me ka ʻeha ʻeha o ka umauma. Hoʻokuʻu ʻia ia ma nā kūlana naʻau ʻē aʻe ma mua o ka infarction myocardial acute (AMI), e like me ka angina unstable, congestive heart failure, a me ka pōʻino ischemic mai ke kāʻei ʻana i ke aʻa coronary. Ma muli o kona kūlana kiʻekiʻe a me ka naʻau no ka ʻiʻo myocardial, ʻo troponin I kēia ka biomarker makemake loa no MI.

Myoglobin/CK-MB/Troponin Ⅰ Ho'āʻo Combo

ʻO ka Myoglobin/CK-MB/Troponin Ⅰ Combo Test he hōʻike maʻalahi e hoʻohana ana i ka hui pū ʻana o MYO/CK-MB/cTnI nā ʻāpana antibody-coated a hopu i nā reagents e ʻike pono iā MYO, CK-MB, a me cTnI i ke koko holoʻokoʻa, serum, a i ʻole plasma.