Ikizamini Myoglobin / CK-MB / Troponin TestIkizamini
Ibisobanuro bigufi:
 Ibisubizo Byihuse: Laboratoire-Nukuri muminota | Laboratoire-Icyiciro Cyuzuye: Yizewe & Yizewe |
| Ikizamini Ahantu hose: Nta laboratoire isabwa | Ubwiza bwemewe: 13485, CE, Mdsap Yubahiriza |
| Byoroheje & Byoroheje: Byoroshye-Gukoresha, Zeru Hassle | Amahirwe meza: Gerageza neza murugo |
Myoglobin (MYO)
Myoglobin (MYO) ni heme-proteine isanzwe iboneka mu mitsi ya skeletale na cardiac, ifite uburemere bwa 17.8 kDa. Igizwe na 2% bya poroteyine yuzuye kandi ishinzwe gutwara ogisijeni mu ngirabuzimafatizo.
Iyo ingirangingo z'imitsi zangiritse, myoglobine irekurwa vuba mumaraso kubera ubunini bwayo. Nyuma y'urupfu rwa tissue ifitanye isano n'indwara ya myocardial (MI), myoglobine ni kimwe mu bimenyetso bya mbere byazamutse hejuru y'urwego rusanzwe:
- Yiyongera cyane hejuru yibanze mugihe cyamasaha 2-4 nyuma ya infarct.
- Impinga kumasaha 9-12.
- Garuka kumurongo mugihe cyamasaha 24-36.
Raporo nyinshi zerekana ko infashanyo yo gupima myoglobine mu kwemeza ko nta infarction ya myocardial ihari, hamwe n’indangagaciro mbi zo guhanura zigera ku 100% zavuzwe mu gihe runaka nyuma y’ibimenyetso bitangiye.
Kurema Kinase MB (CK-MB)
Creatine kinase MB (CK-MB) ni enzyme igaragara mumitsi yumutima, ifite uburemere bwa molekile ya 87.0 kDa. Creatine kinase ni molekile ya dimeric ikozwe muri subunits ebyiri ("M" na "B"), zihuza gukora isoenzymes eshatu: CK-MM, CK-BB, na CK-MB. CK-MB ni isoenzyme igira uruhare runini muri metabolism yimitsi yumutima.
Gukurikira MI, CK-MB irekura mumaraso irashobora kumenyekana mugihe cyamasaha 3-8 nyuma yikimenyetso:
- Impinga mu masaha 9-30.
- Garuka kumurongo mugihe cyamasaha 48-72.
CK-MB ni kimwe mu bimenyetso byingenzi byumutima kandi bizwi cyane nkibimenyetso gakondo byo gusuzuma MI.
Cardiac Troponin I (cTnI)
Cardiac troponin I (cTnI) ni poroteyine iboneka mu mitsi yumutima, ifite uburemere bwa 22.5 kDa. Nibice bigize subunit eshatu (hamwe na troponine T na troponine C); hamwe na tropomyosine, iyi complexe igenga calcium-yumvisha ibikorwa bya ATPase ya actomyosine mumitsi ya skeletale na cardiac.
Nyuma yo gukomeretsa k'umutima, troponine I irekurwa mumaraso nyuma yamasaha 4-6 nyuma yububabare butangiye. Uburyo bwo kurekura busa na CK-MB, ariko mugihe CK-MB isubiye mubisanzwe mugihe cyamasaha 72, troponine I ikomeza kuzamuka muminsi 6-10 - itanga idirishya rirerire ryerekana ibikomere byumutima.
cTnI ifite umwihariko wo kwangirika kwa myocardial, yerekanwe mubihe nkigihe cya perioperative, kwiruka nyuma ya marato, no guhahamuka mu gatuza. Irekurwa kandi mubihe byumutima usibye infarction ikaze ya myocardial (AMI), nka angina idahindagurika, kunanirwa k'umutima, hamwe no kwangirika kwa ischemic biturutse kubagwa byamaraso. Bitewe numwihariko wacyo hamwe nubukangurambaga kuri myocardial tissue, troponin I ubu ni biomarker ikunzwe cyane kuri MI.
Myoglobin / CK-MB / Troponin Test Ikizamini cya Combo
Myoglobin / CK-MB / Troponin Test Ikizamini cya Combo ni isuzuma ryoroshye rikoresha uruvange rwa MYO / CK-MB / cTnI antibody zifatanije na antibody no gufata reagent kugirango uhitemo neza MYO, CK-MB, na cTnI mumaraso yose, serumu, cyangwa plasma.
