Testsealabs COT Cotinine Test
Tsanangudzo Pfupi
Iyo COT Cotinine Muedzo (Weti) ndeye lateral kuyerera chromatographic immunoassay yemhando yekuona cotinine muweti.
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Cotinine ndiyo yekutanga-nhanho metabolite yechikakananda, ine chepfu alkaloid inoburitsa kukurudzira kwe autonomic ganglia uye yepakati tsinga system muvanhu.
Nicotine mushonga unoburitswa munhengo yese yeboka rinoputa fodya, kungave kuburikidza nekubata zvakananga kana kufemerwa neruoko rwechipiri. Pamusoro pefodya, chikakananda chinowanikwawo mukutengesa sechinhu chinoshanda mumishonga yekutsiva yekuputa senge nicotine chingamu, zvigamba zvetransdermal, uye zvipfapfaidzo zvemhino.
Mumuenzaniso weti yeawa ye24, inenge 5% yepicotine dose inobudiswa semushonga usina kuchinjwa, ne10% secotinine uye 35% sehydroxyl cotinine; kuwanda kwemamwe metabolites anotendwa kuverengera isingasviki 5%.
Kunyange zvazvo cotinine ichifungidzirwa kuva isingashandisi metabolite, kubviswa kwayo kwakagadzikana kudarika iyo nicotine, iyo inonyanya kutsamira weti pH. Nekuda kweizvozvo, cotinine inoonekwa seyakanaka biological marker yekuona kushandisa nicotine.
Iyo plasma hafu yeupenyu yechikakananda ingangoita maminetsi makumi matanhatu mushure mekufemerwa kana kutungamirwa nevabereki. Nicotine uye cotinine zvinokurumidza kubviswa neitsvo; hwindo rekuonekwa kwecotinine muweti padanho rekuchekwa re200 ng/mL rinotarisirwa kusvika mazuva maviri kusvika matatu mushure mekushandisa nicotine.
COT Cotinine Test (Weti) inopa mhedzisiro yakanaka kana cotinine iri muweti inodarika 200 ng/mL.
