Testsealabs Myoglobin/CK-MB/Troponin ⅠCombo Test
Tsanangudzo Pfupi
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Myoglobin (MYO)
Myoglobin (MYO) iheme-protein inowanzowanikwa mumaskeletal uye mhasuru dzemwoyo, ine huremu hwe17.8 kDa. Inoumba inenge 2% yeprotein yemhasuru yakazara uye ine basa rekutakura okisijeni mukati memasero etsandanyama.
Kana masero emhasuru akuvadzwa, myoglobin inokurumidza kuburitswa muropa nekuda kwehukuru hwayo hudiki. Kutevera kufa kwenyama kwakabatana nemyocardial infarction (MI), myoglobin ndeimwe yekutanga mamakisi kukwira pamusoro peyakajairika:
- Inowedzera kuyerwa pamusoro pekutanga mukati meawa 2-4 mushure me-infarct.
- Peaks pa9-12 maawa.
- Inodzokera kune yekutanga mukati meawa 24-36.
Mishumo yakawanda inoratidza myoglobin kuyerwa kwekubatsira mukusimbisa kusavapo kwemyocardial infarction, ine maitiro asina kunaka ekufungidzira kusvika ku100% akashumwa panguva dzakatarwa dzenguva mushure mekutanga kwechiratidzo.
Creatine Kinase MB (CK-MB)
Creatine kinase MB (CK-MB) is enzyme iripo mumhasuru yemwoyo, ine molecular uremu hwe87.0 kDa. Creatine kinase idimeric molecule inoumbwa kubva kune maviri subunits ("M" uye "B"), ayo anobatana kuita matatu isoenzymes: CK-MM, CK-BB, uye CK-MB. CK-MB ndiyo isoenzyme inonyanya kubatanidzwa mumetabolism yemwoyo mhasuru tishu.
Kutevera MI, CK-MB kuburitswa muropa inogona kuonekwa mukati meawa 3-8 mushure mekutanga kwechiratidzo:
- Peaks mukati maawa 9-30.
- Inodzokera kune yekutanga mukati me48-72 maawa.
CK-MB ndechimwe chezvicherechedzo zvemoyo zvakakosha uye inozivikanwa zvakanyanya sechinyakare chiratidzo chekuongorora MI.
Cardiac Troponin I (cTnI)
Cardiac troponin I (cTnI) ipuroteni inowanikwa mumhasuru yemwoyo, ine molecular uremu hwe22.5 kDa. Icho chikamu chetatu-subunit complex (pamwe chete netroponin T uye troponin C); pamwe chete ne tropomyosin, iyi yakaoma inodzora calcium-sensitive ATPase chiitiko che actomyosin mu striated skeletal uye yemwoyo tsandanyama.
Mushure mekukuvara kwemoyo, troponin I inosunungurwa muropa maawa 4-6 mushure mekurwadziwa kwekutanga. Kusunungurwa kwayo kwakafanana neCK-MB, asi nepo CK-MB ichidzokera kune yakajairika mukati meawa 72, troponin I inoramba yakasimudzwa kwemazuva 6-10-inopa nguva yakareba yekuona hwindo rekukuvara kwemwoyo.
cTnI ine yakakwira chaiyo yekukuvadzwa kwemyocardial, inoratidzwa mumamiriro ezvinhu senge nguva yeperioperative, post-marathon inomhanya, uye blunt chipfuva trauma. Inosunungurwawo mumamiriro emwoyo kunze kweacute myocardial infarction (AMI), yakadai seangina isina kugadzikana, congestive heart failure, uye ischemic kukuvara kubva pakuvhiyiwa kwecoronary artery bypass. Nekuda kwekunyanya kwayo uye kunzwisiswa kwemyocardial tishu, troponin I ikozvino ndiyo inonyanya kufarirwa biomarker yeMI.
Myoglobin/CK-MB/Troponin Ⅰ Combo Test
Iyo Myoglobin/CK-MB/Troponin Ⅰ Combo Test chiyedzo chiri nyore chinoshandisa musanganiswa weMYO/CK-MB/cTnI antibody-coated particles uye zvinotora reagents kuti zvisarudze kuona MYO, CK-MB, uye cTnI muropa rose, serum, kana plasma.
