Testsealabs Myoglobin/CK-MB/Troponin ⅠCombo Test
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Myoglobin (MYO)
Myoglobin (MYO) yog ib qho heme-protein ib txwm pom nyob rau hauv cov pob txha pob txha thiab lub plawv, nrog rau qhov hnyav ntawm 17.8 kDa. Nws suav txog li 2% ntawm tag nrho cov leeg nqaij protein thiab yog lub luag haujlwm thauj cov pa oxygen hauv cov leeg nqaij.
Thaum cov leeg nqaij puas lawm, myoglobin tau tso tawm sai sai rau hauv cov ntshav vim nws qhov me me. Tom qab cov ntaub so ntswg tuag cuam tshuam nrog myocardial infarction (MI), myoglobin yog ib qho ntawm thawj cov cim kom nce siab tshaj li ib txwm:
- Nws nce ntsuas saum toj kawg nkaus hauv 2-4 teev tom qab infarct.
- Peaks ntawm 9-12 teev.
- Rov qab mus rau hauv paus hauv 24-36 teev.
Ntau cov ntawv tshaj tawm qhia txog kev ntsuas kev ntsuas myoglobin hauv kev lees paub qhov tsis muaj myocardial infarction, nrog rau qhov kev kwv yees tsis zoo txog li 100% tau tshaj tawm nyob rau lub sijhawm tshwj xeeb tom qab cov tsos mob tshwm sim.
Creatine Kinase MB (CK-MB)
Creatine kinase MB (CK-MB) yog ib qho enzyme uas muaj nyob rau hauv cov leeg mob plawv, nrog rau qhov hnyav molecular ntawm 87.0 kDa. Creatine kinase yog dimeric molecule tsim los ntawm ob lub subunits ("M" thiab "B"), uas ua ke los ua peb isoenzymes: CK-MM, CK-BB, thiab CK-MB. CK-MB yog isoenzyme feem ntau koom nrog hauv cov metabolism hauv cov leeg nqaij.
Ua raws li MI, CK-MB tso tawm rau hauv cov ntshav tuaj yeem kuaj pom tsis pub dhau 3-8 teev tom qab cov tsos mob tshwm sim:
- Peaks hauv 9-30 teev.
- Rov qab mus rau qhov pib hauv 48-72 teev.
CK-MB yog ib qho ntawm cov cim tseem ceeb tshaj plaws ntawm lub plawv thiab tau txais kev lees paub dav dav raws li cov cim cim rau kev kuaj mob MI.
Cardiac Troponin I (cTnI)
Cardiac troponin I (cTnI) yog cov protein uas muaj nyob hauv cov leeg mob plawv, nrog rau qhov hnyav molecular ntawm 22.5 kDa. Nws yog ib feem ntawm peb-subunit complex (nrog rau troponin T thiab troponin C); Ua ke nrog tropomyosin, qhov complex no tswj cov calcium-sensitive ATPase kev ua ntawm actomyosin hauv striated skeletal thiab cardiac nqaij.
Tom qab mob plawv, troponin I raug tso rau hauv cov ntshav 4-6 teev tom qab qhov mob tshwm sim. Nws cov qauv tso tawm zoo ib yam li CK-MB, tab sis thaum CK-MB rov zoo li qub hauv 72 teev, troponin kuv tseem nce siab rau 6-10 hnub - muab lub qhov rai tshawb pom ntev dua rau kev mob plawv.
cTnI muaj qhov tshwj xeeb tshwj xeeb rau kev puas tsuaj rau myocardial, pom nyob rau hauv cov xwm txheej zoo li lub sijhawm perioperative, post-marathon khiav, thiab blunt mob hauv siab. Nws tseem raug tso tawm hauv cov mob plawv uas tsis yog mob myocardial infarction (AMI), xws li tsis ruaj khov angina, lub plawv tsis ua haujlwm, thiab ischemic puas tsuaj los ntawm kev phais mob plawv. Vim nws qhov tshwj xeeb siab thiab rhiab heev rau cov ntaub so ntswg myocardial, troponin I yog tam sim no nyiam tshaj plaws biomarker rau MI.
Myoglobin/CK-MB/Troponin Ⅰ Combo Test
Myoglobin / CK-MB / Troponin Ⅰ Combo Test yog ib qho kev sim yooj yim uas siv kev sib xyaw ua ke ntawm MYO / CK-MB / cTnI cov tshuaj tiv thaiv kab mob coated thiab ntes cov reagents los xaiv MYO, CK-MB, thiab cTnI hauv cov ntshav, ntshav, lossis ntshav.
