Zatsopano za IVD Detection Reagents Kusintha Kuzindikira kwa Arbovirus

Kachilombo ka Zika, yemwe ali m'banja la Flaviviridae, amafala makamaka kwa anthu mwa kulumidwa ndi udzudzu wa Aedes, monga Aedes aegypti ndi Aedes albopictus. Kachilomboka kanadziwika koyamba mu 1947 m'nkhalango ya Zika ku Uganda, komwe adatalikirana ndi nyani wa rhesus. Kwa zaka zambiri, matenda a Zika anali osowa kwambiri ndipo amangochitika mwapang'onopang'ono ku Africa ndi Asia, ndipo matenda ambiri amayambitsa zizindikiro zochepa kapena zosaoneka. Komabe, mu 2015, mliri waukulu unachitika ku Brazil, womwe unafalikira mofulumira ku mayiko ena ku Latin America, Caribbean, ndi kupitirira, kukopa chidwi cha dziko lonse.

Zizindikiro za matenda a Zika kachilombo kaŵirikaŵiri zimakhala zochepa ndipo zingaphatikizepo kutentha thupi, zidzolo, kupweteka kwa mafupa, kupweteka kwa minofu, mutu, ndi conjunctivitis. Zizindikirozi zimawonekera patatha masiku awiri kapena 7 mutalumidwa ndi udzudzu womwe uli ndi kachilomboka ndipo zimatha masiku awiri mpaka 7. Ngakhale kuti anthu ambiri amachira popanda mavuto aakulu, kachilombo ka Zika kamakhala kogwirizana ndi matenda aakulu a ubongo, makamaka microcephaly mwa makanda obadwa ndi amayi omwe ali ndi kachilombo panthawi yomwe ali ndi pakati, ndi Guillain-Barré syndrome mwa akuluakulu.

Poyang'anizana ndi chiwopsezo chosalekeza chobwera ndi arboviruses monga Zika, Chikungunya, ndi Dengue,Testsealabsyakhazikitsa gulu la advanced in vitro diagnostic (IVD) reagents, zomwe zikuwonetsa kulumpha kwakukulu pakuwunika kolondola komanso kofulumira kwa matendawa. Ma reagents awa, kuphatikiza Mayeso a Zika Virus Antibody IgG/IgM, ZIKA IgG/IgM/Chikungunya IgG/IgM Combo Test, ndi Dengue NS1/Dengue IgG/IgM/Zika Virus IgG/IgM Combo Test, pamodzi ndi Dengue Dengue NS1/Dengue IgG/IgM Mayeso a IgG/IgM/Chikungunya, akhazikitsidwa kuti asinthe mawonekedwe a matenda a arbovirus.

Chovuta chachikulu pothana ndi ma arboviruses ndikuti zizindikiro zawo zoyambirira zimakhala zofanana kwambiri, zomwe nthawi zambiri zimayambitsa kusazindikira. Gome lotsatirali likuwonetsa zizindikiro zodziwika bwino za Zika, Dengue, ndi Chikungunya, komanso zambiri zachipatala, zomwe zikuwonetsa chifukwa chake chisokonezo chimayamba:

*Kutengera kafukufuku wa 2024 wokhudza odwala 1,200 m'madera otentha

**Kuphatikiza kusonkhanitsa zitsanzo, mayendedwe, ndi kuyesa motsatizana

Chifukwa cha kufanana kochititsa chidwi kwa zizindikiro zoyamba komanso kuchuluka kwa matenda olakwika (kupitirira 50% pa mavairasi onse atatu), n'kovuta kwambiri kwa opereka chithandizo chamankhwala kusiyanitsa pakati pa matendawa malinga ndi momwe akuchipatala. Nthawi yayitali yofunikira kuti itsimikizidwe ndi mayeso amodzi imachedwetsanso chithandizo ndi kuwongolera kufalikira. Apa ndipamene mayeso athu a combo amayambira. Kumanga pamaziko a mayeso a khadi limodzi, tapanga zida zowunikira zophatikiza makhadi ambiri zomwe zimatha kuzindikira matenda angapo pakuyezetsa kumodzi, kuchepetsa nthawi yozindikira matenda mpaka 70% ndikuchepetsa kuchuluka kwa matenda olakwika mpaka pansi pa 5% m'mayesero azachipatala.

Mayeso a Zika Virus Antibody IgG/IgM: Kuzindikira Matenda a Zika ndi Precision

Kuyeza kwa Zika Virus Antibody IgG/IgM ndi kuyesa kofulumira kwa ma chromatographic immunoassay opangidwa kuti athe kuzindikira bwino za ma antibodies a IgG ndi IgM ku kachilombo ka Zika m'magazi amunthu, seramu, kapena plasma. Kuyeza uku kumagwira ntchito ngati chithandizo chofunikira pakuzindikira matenda a Zika virus. Pozindikira kukhalapo kwa ma antibodies awa, othandizira azaumoyo amatha kudziwa ngati wodwala wadwala posachedwa (IgM positive) kapena adakhalapo kale (IgG positive).

Ubwino wa Zamalonda: Mayesowa amawonekera kwambiri ndi kukhudzidwa kwake kopitilira muyeso (98.6% m'mayesero azachipatala), amatha kuzindikira ma antibodies ngakhale m'magawo oyambilira a matenda pomwe ma antibodies ali otsika. Kukhazikika kwake kwapadera (99.2%) kumachepetsa kuyanjananso ndi ma antibodies ochokera ku ma flavivirus okhudzana, kuonetsetsa zotsatira zodalirika. Komanso, zida zoyesera zimapangidwira kukhazikika kwanthawi yayitali, ndi alumali moyo wa miyezi 24 ikasungidwa pa 2-8 ° C, kuchepetsa zinyalala ndikuwonetsetsa kupezeka kumadera akutali okhala ndi zida zochepa zozizira.

ZIKA IgG/IgM/Chikungunya IgG/IgM Combo Test: Dual Diagnosis for Related Arboviruses

ZIKA IgG/IgM/Chikungunya IgG/IgM Combo Test ndi chida chosinthira chomwe chimalola kuzindikira ndi kusiyanitsa nthawi imodzi ya ma immunoglobulin M (IgM) ndi ma immunoglobulin G (IgG) ku virus ya Zika ndi kachilombo ka Chikungunya. Chikungunya, monga Zika, ndi matenda oyambitsidwa ndi udzudzu omwe angayambitse kupweteka kwakukulu, kutentha thupi, ndi kutupa.

Ubwino wa Zamalonda: Kuyesa kwa combo kumeneku kumathetsa kufunika koyesa kosiyana kwa Zika ndi Chikungunya, kuchepetsa nthawi yoyesera ndi 50% poyerekeza ndi mayesero a munthu aliyense (kuyambira maola 52 mpaka 20 mphindi). Imagwiritsa ntchito njira yapadera yodziwira njira ziwiri zomwe zimatsimikizira kusiyanitsa bwino pakati pa ma virus awiriwa, okhala ndi chiwopsezo chochepera 1%, kupewa chisokonezo chomwe chingabwere chifukwa cha matenda ofanana. Kuyesedwa kumafunikanso voliyumu yaying'ono (5µL yokha), kuti ikhale yabwino kwa odwala, makamaka ana ndi okalamba.

Dengue NS1/Dengue IgG/IgM/Zika Virus IgG/IgM Combo Test: A Holistic Approach to Arbovirus Diagnosis

Dengue NS1/Dengue IgG/IgM/Zika Virus IgG/IgM Combo Test ndi yankho lathunthu lomwe silimangozindikira kupezeka kwa kachilombo ka Dengue pozindikira ma NS1 antigen, IgG, ndi IgM achitetezo komanso amawonetsa ma antibodies a Zika virus IgG ndi IgM. Dengue ndi vuto lalikulu laumoyo wa anthu m'madera ambiri otentha ndi otentha, kuchititsa zizindikiro zosiyanasiyana kuchokera ku matenda a chimfine pang'ono kupita ku chimfine choopsa komanso choopsa kwambiri cha dengue hemorrhagic fever.

Ubwino wa Zamalonda: Kuphatikizika kwa NS1 antigen kuzindikira kumathandizira kuzindikira koyambirira kwa Dengue patangotha ​​​​masiku 1-2 chiyambireni zizindikiro, ndi kukhudzika kwa 97.3% kwa kuzindikira kwa NS1, komwe ndikofunikira kuti muthe kulandira chithandizo chanthawi yake kuti mupewe zovuta zazikulu (zomwe zimachitika mu 10-20% ya milandu yosachiritsidwa). Kuzindikira kwamitundu yambiri (NS1, IgG, IgM ya Dengue ndi IgG, IgM ya Zika) kumapereka mbiri yowunikira, kuthandiza othandizira azaumoyo kumvetsetsa gawo la matenda ndikusankha bwino chithandizo. Kuphatikiza apo, mayesowa adatsimikiziridwa kuti agwiritsidwe ntchito m'malo osiyanasiyana azachipatala, kuwonetsa magwiridwe antchito m'ma laboratories osiyanasiyana okhala ndi coefficient of variation (CV) yochepera 5%.

Dengue NS1/Dengue IgG/IgM/Zika Virus IgG/IgM/Chikungunya Test: The Ultimate Arbovirus Diagnostic Tool

Mayeso a Dengue NS1/Dengue IgG/IgM/Zika Virus IgG/IgM/Chikungunya amatengera matenda a arbovirus kupita pamlingo wina pophatikiza kuthekera kozindikira kwa mayeso onse am'mbuyomu ndikuwonjezera kuzindikira kwa ma antibodies a Chikungunya virus IgG ndi IgM. Mayeso amtundu umodziwa adapangidwa kuti apereke chidziwitso chokwanira komanso cholondola cha matenda a arbovirus angapo muyeso limodzi.

Ubwino wa Zamalonda: Mayeso ophatikizika onsewa amapereka mphamvu zosayerekezeka pozindikira ma arbovirus akuluakulu atatu nthawi imodzi, kuchepetsa mtengo wathunthu pa wodwala ndi 40% poyerekeza ndi mayeso amunthu payekha komanso kuchepetsa kwambiri ntchito ya ogwira ntchito m'ma laboratories. Imakhala ndi ukadaulo wapamwamba wokulitsa ma siginecha womwe umakulitsa chidwi chodziwikiratu pazolinga zonse (kukhudzika kwapakati pa 98.1% pa ma analyte onse), kuwonetsetsa kuti ngakhale matenda otsika samaphonya. Mayesowa amabweranso ndi mawonekedwe osavuta kugwiritsa ntchito komanso malangizo omveka bwino omasulira, zomwe zimapangitsa kuti zikhale zosavuta kugwiritsa ntchito ngakhale kwa ogwira ntchito zachipatala osadziwa zambiri, ndi nthawi yophunzitsira ya maola a 2 okha omwe amafunikira kuti azitha kuchita bwino.

Features ndi Ubwino waTestsealabs IVD Detection Reagents

• Zotsatira Zachangu: Mayesero onsewa amapereka zotsatira pakanthawi kochepa, nthawi zambiri mkati mwa mphindi 15, zomwe zimalola kupanga zisankho mwachangu pakuzindikira ndi kuchiza odwala.
• Kukhudzika Kwambiri ndi Kufotokozera: Mayeserowa adapangidwa kuti akhale okhudzidwa kwambiri (≥97%), kuwonetsetsa kuti azindikire ngakhale ma antibodies otsika kapena ma antigen, ndi enieni (≥99%), kuchepetsa chiopsezo cha zolakwika. Izi ndizofunikira kwambiri pakuwunika kolondola komanso kusamalidwa bwino kwa odwala.
• Mitundu ya Zitsanzo Zosinthika: Zitha kugwiritsidwa ntchito ndi mitundu yosiyanasiyana ya zitsanzo, kuphatikizapo ndodo zonse za chala, magazi athunthu a venous, seramu, ndi plasma, zomwe zimapangitsa kuti zikhale zoyenera kuti zigwiritsidwe ntchito pazochitika zosiyanasiyana zachipatala ndi zosamalira.
• Kusavuta Kugwiritsa Ntchito: Mayeserowa ndi osavuta kuchita ndipo amafunikira maphunziro ochepa, kuwapangitsa kuti athe kupezeka kwa opereka chithandizo chamankhwala m'malo olemera komanso opanda zida.
• Zotsatira za Zolinga: Mayesero ambiri, monga omwe amagwiritsa ntchito luso lamakono la DPP (Dual Path Platform), amapereka zotsatira zomveka pogwiritsa ntchito chowerengera chosavuta cham'manja cha digito, kuchepetsa kuthekera kwa zolakwika zaumunthu pakutanthauzira zotsatira.

Mapeto

Testsealabsmitundu yatsopano ya ma reagents ozindikira IVD a Zika, Chikungunya, ndi ma virus a Dengue akuyimira kupita patsogolo kwakukulu pantchito yozindikira matenda a arbovirus. Poganizira kufanana kwakukulu kwa zizindikiro zoyamba komanso kuchuluka kowopsa kwa matenda olakwika (opitilira 50%) pakati pa matendawa, mayeso athu a combo, opangidwa kuchokera ku mayeso a khadi limodzi, omwe amatha kuzindikira matenda angapo nthawi imodzi ndi matenda olakwika omwe ali pansi pa 5% komanso nthawi zodziwikiratu pansi pa mphindi 20, ndizofunika kwambiri. Ndi ubwino wawo wapadera wa mankhwala kuphatikizapo kukhudzika kwakukulu, kukhazikika, kuchita bwino, komanso kugwiritsa ntchito mosavuta, ma reagentswa amaikidwa kuti afotokozenso momwe matenda a arbovirus amazindikirira ndikusamalidwa. Popereka othandizira azaumoyo zida zowunikira zolondola, zofulumira, komanso zatsatanetsatane, ma reagentswa ali ndi kuthekera kopititsa patsogolo zotsatira za odwala, kupititsa patsogolo kuyang'anira matenda, ndikuthandizira kuwongolera bwino kwa kuphulika kwa arbovirus. Pamene katundu wapadziko lonse wa matenda a arbovirus akukulirakulirabe, mayeso atsopanowa akhazikitsidwa kuti agwire ntchito yofunika kwambiri polimbana ndi ziwopsezo zofunika kwambiri paumoyo wa anthu.