Testsealabs Myoglobin/CK-MB/Troponin ⅠCombo Test
Kufotokozera Kwachidule:
 Zotsatira Zachangu: Labu-Yolondola Mphindi | Lab-Grade Precision: Odalirika & Odalirika |
| Yesani Kulikonse: Palibe Kuyendera Labu Kofunikira | Ubwino Wotsimikizika: 13485, CE, Mdsap Compliant |
| Zosavuta & Zosavuta: Zosavuta Kugwiritsa Ntchito, Zovuta Zero | Kusavuta Kwambiri: Yesani Momasuka Kunyumba |
Myoglobin (MYO)
Myoglobin (MYO) ndi mapuloteni a heme omwe amapezeka m'mitsempha ya chigoba ndi mtima, yomwe imakhala ndi kulemera kwa 17.8 kDa. Zimapanga pafupifupi 2% ya mapuloteni onse a minofu ndipo ali ndi udindo woyendetsa mpweya mkati mwa maselo a minofu.
Maselo a minofu akawonongeka, myoglobin imatulutsidwa mofulumira m'magazi chifukwa cha kukula kwake kochepa. Kutsatira kufa kwa minofu yolumikizidwa ndi myocardial infarction (MI), myoglobin ndi imodzi mwazolembera zoyamba kukwera pamwamba pamlingo wabwinobwino:
- Imachulukirachulukira pamtunda woyambira mkati mwa maola 2-4 pambuyo pa infarct.
- Pamaso pa maola 9-12.
- Imabwereranso pazoyambira mkati mwa maola 24-36.
Malipoti angapo akuwonetsa kuti kuyeza kwa myoglobin kumathandizira kutsimikizira kusakhalapo kwa infarction ya myocardial, ndi malingaliro oyipa omwe amafika mpaka 100% omwe adanenedwa panthawi inayake pambuyo pa kuyambika kwa chizindikiro.
Creatine Kinase MB (CK-MB)
Creatine kinase MB (CK-MB) ndi puloteni yomwe ilipo mu minofu ya mtima, yomwe imakhala ndi kulemera kwa 87.0 kDa. Creatine kinase ndi molekyulu ya dimeric yopangidwa kuchokera kumagulu awiri ("M" ndi "B"), omwe amaphatikiza kupanga ma isoenzymes atatu: CK-MM, CK-BB, ndi CK-MB. CK-MB ndiye isoenzyme yomwe imakhudzidwa kwambiri ndi metabolism ya minofu yamtima.
Kutsatira MI, kutulutsidwa kwa CK-MB m'magazi kumatha kudziwika mkati mwa maola 3-8 chiyambireni chizindikiro:
- Imafika pachimake mkati mwa maola 9-30.
- Imabwereranso pazoyambira mkati mwa maola 48-72.
CK-MB ndi imodzi mwazolemba zofunika kwambiri zamtima ndipo imadziwika kwambiri ngati chizindikiro chachikhalidwe pozindikira MI.
Cardiac Troponin I (cTnI)
Cardiac troponin I (cTnI) ndi puloteni yomwe imapezeka mu minofu ya mtima, yomwe imakhala ndi kulemera kwa 22.5 kDa. Ndi gawo la magawo atatu a subunit (pamodzi ndi troponin T ndi troponin C); pamodzi ndi tropomyosin, zovutazi zimayendetsa ntchito ya ATPase ya calcium-sensitive ya actomyosin mu striated chigoba ndi mtima minofu.
Pambuyo pa kuvulala kwa mtima, troponin I imatulutsidwa m'magazi maola 4-6 pambuyo pa kupweteka. Njira yake yotulutsidwa ndi yofanana ndi CK-MB, koma pamene CK-MB imabwereranso mkati mwa maola a 72, troponin I imakhalabe pamwamba kwa masiku a 6-10-kupereka zenera lodziwikiratu la kuvulala kwa mtima.
cTnI imakhala yodziwika kwambiri pakuwonongeka kwa myocardial, zomwe zimawonetsedwa ngati nthawi ya opaleshoni, kuthamanga kwapambuyo pa marathon, komanso kuvulala pachifuwa. Imatulutsidwanso m'mikhalidwe yamtima kupatulapo acute myocardial infarction (AMI), monga angina wosakhazikika, kulephera kwa mtima, komanso kuwonongeka kwa ischemic kuchokera ku opaleshoni yodutsa mtsempha wamagazi. Chifukwa cha kutsimikizika kwake komanso kukhudzika kwa minofu ya myocardial, troponin I tsopano ndiye biomarker yomwe imakonda kwambiri MI.
Myoglobin/CK-MB/Troponin Ⅰ Combo Test
The Myoglobin/CK-MB/Troponin Ⅰ Combo Test ndi kuyesa kosavuta komwe kumagwiritsa ntchito tinthu tating'ono ta MYO/CK-MB/cTnI ndi ma reagents kuti azindikire MYO, CK-MB, ndi cTnI m'magazi athunthu, seramu, kapena plasma.
