Testsealabs COT Cotinine Test
Short Description:
The COT Cotinine Test (Urine) is a lateral flow chromatographic immunoassay for the qualitative detection of cotinine in urine.
 Rapid Results: Lab-Accurate in Minutes |
Lab-Grade Precision: Reliable & Trustworthy |
| Test Anywhere: No Lab Visit Required |
Certified Quality: 13485, CE, Mdsap Compliant |
| Simple & Streamlined: Easy-to-Use, Zero Hassle |
Ultimate Convenience: Test Comfortably at Home |
Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produces stimulation of the autonomic ganglia and central nervous system in humans.
Nicotine is a drug to which virtually every member of a tobacco-smoking society is exposed, whether through direct contact or second-hand inhalation. In addition to tobacco, nicotine is also commercially available as the active ingredient in smoking replacement therapies such as nicotine gum, transdermal patches, and nasal sprays.
In a 24-hour urine sample, approximately 5% of a nicotine dose is excreted as the unchanged drug, with 10% as cotinine and 35% as hydroxyl cotinine; the concentrations of other metabolites are believed to account for less than 5%.
While cotinine is thought to be an inactive metabolite, its elimination profile is more stable than that of nicotine, which is largely urine pH dependent. As a result, cotinine is considered a good biological marker for determining nicotine use.
The plasma half-life of nicotine is approximately 60 minutes following inhalation or parenteral administration. Nicotine and cotinine are rapidly eliminated by the kidney; the window of detection for cotinine in urine at a cut-off level of 200 ng/mL is expected to be up to 2–3 days after nicotine use.
The COT Cotinine Test (Urine) yields a positive result when the cotinine in urine exceeds 200 ng/mL.
