Testsealabs Myoglobin/CK-MB/Troponin ⅠCombo Test
Short Description:
 Rapid Results: Lab-Accurate in Minutes |
Lab-Grade Precision: Reliable & Trustworthy |
| Test Anywhere: No Lab Visit Required |
Certified Quality: 13485, CE, Mdsap Compliant |
| Simple & Streamlined: Easy-to-Use, Zero Hassle |
Ultimate Convenience: Test Comfortably at Home |
Myoglobin (MYO)
Myoglobin (MYO) is a heme-protein normally found in skeletal and cardiac muscle, with a molecular weight of 17.8 kDa. It constitutes about 2% of total muscle protein and is responsible for transporting oxygen within muscle cells.
When muscle cells are damaged, myoglobin is rapidly released into the blood due to its relatively small size. Following tissue death associated with myocardial infarction (MI), myoglobin is one of the first markers to rise above normal levels:
- It increases measurably above baseline within 2–4 hours post-infarct.
- Peaks at 9–12 hours.
- Returns to baseline within 24–36 hours.
Several reports suggest myoglobin measurement aids in confirming the absence of myocardial infarction, with negative predictive values of up to 100% reported during specific time periods after symptom onset.
Creatine Kinase MB (CK-MB)
Creatine kinase MB (CK-MB) is an enzyme present in cardiac muscle, with a molecular weight of 87.0 kDa. Creatine kinase is a dimeric molecule formed from two subunits ("M" and "B"), which combine to form three isoenzymes: CK-MM, CK-BB, and CK-MB. CK-MB is the isoenzyme most involved in the metabolism of cardiac muscle tissue.
Following MI, CK-MB release into the blood can be detected within 3–8 hours after symptom onset:
- Peaks within 9–30 hours.
- Returns to baseline within 48–72 hours.
CK-MB is one of the most important cardiac markers and is widely recognized as the traditional marker for diagnosing MI.
Cardiac Troponin I (cTnI)
Cardiac troponin I (cTnI) is a protein found in cardiac muscle, with a molecular weight of 22.5 kDa. It is part of a three-subunit complex (along with troponin T and troponin C); together with tropomyosin, this complex regulates the calcium-sensitive ATPase activity of actomyosin in striated skeletal and cardiac muscle.
After cardiac injury, troponin I is released into the blood 4–6 hours after pain onset. Its release pattern is similar to CK-MB, but while CK-MB returns to normal within 72 hours, troponin I remains elevated for 6–10 days—providing a longer detection window for cardiac injury.
cTnI has high specificity for myocardial damage, demonstrated in conditions like the perioperative period, post-marathon runs, and blunt chest trauma. It is also released in cardiac conditions other than acute myocardial infarction (AMI), such as unstable angina, congestive heart failure, and ischemic damage from coronary artery bypass surgery. Due to its high specificity and sensitivity for myocardial tissue, troponin I is now the most preferred biomarker for MI.
Myoglobin/CK-MB/Troponin Ⅰ Combo Test
The Myoglobin/CK-MB/Troponin Ⅰ Combo Test is a simple assay that uses a combination of MYO/CK-MB/cTnI antibody-coated particles and capture reagents to selectively detect MYO, CK-MB, and cTnI in whole blood, serum, or plasma.
