Testsealabs PGB Pregabalin Test
Pregabalin, an analog of the inhibitory neurotransmitter gamma-aminobutyric acid and also of gabapentin, has been used clinically since 2002 as an analgesic, anticonvulsant, and anxiolytic agent.
It is supplied as the free drug in 25–300 mg capsules for oral administration. Adult doses are normally within a range of 50–200 mg thrice daily.
A single oral labeled dose of pregabalin in humans was eliminated in urine (92%) and feces (<0.1%) over a 4-day period. Urinary excretion products included unchanged drug (90% of the dose), N-Methylpregabalin (0.9%), and others.
Single oral 75 or 150 mg doses given to healthy humans yielded peak urinary pregabalin concentrations of 151 or 214 μg/mL, respectively, in the first 8-hour specimen.
Pregabalin urine levels in 57,542 specimens from chronic pain patients averaged 184 μg/mL.
The PGB Pregabalin Test yields a positive result when the pregabalin level in urine exceeds 2,000 ng/mL.

