Testsealabs PSA Prostate Specific Antigen Test
Prostate Specific Antigen (PSA) is a single-chain glycoprotein with a molecular weight of approximately 34 kDa. It exists in three major forms circulating in the serum:
- Free PSA
- PSA bound to α1-antichymotrypsin (PSA-ACT)
- PSA complexed with α2-macroglobulin (PSA-MG)
PSA has been detected in various tissues of the male urogenital system, but it is exclusively secreted by prostate glandular and endothelial cells.
In healthy men, the serum PSA level ranges between 0.1 ng/mL and 4 ng/mL. Elevated PSA levels can occur in both malignant and benign conditions:
- Malignant conditions: e.g., prostate cancer
- Benign conditions: e.g., benign prostatic hyperplasia (BPH) and prostatitis
PSA level interpretations:
- A level of 4 to 10 ng/mL is considered the "gray zone."
- Levels above 10 ng/mL are highly indicative of cancer.
- Patients with PSA values between 4–10 ng/mL should undergo further prostate analysis via biopsy.
The PSA test is the most valuable tool for diagnosing early prostate cancer. Numerous studies have confirmed that PSA is the most useful and meaningful tumor marker for prostate cancer, prostate infections, and BPH.
The PSA Prostate Specific Antigen Test utilizes a combination of colloidal gold conjugate and PSA antibody to selectively detect total PSA in whole blood, serum, or plasma. It has:
- A cut-off value of 4 ng/mL
- A reference value of 10 ng/mL






